LaTeX is an old school but good program. You edit a text file, run the program(s), and it converts your text file to one of many other formats, with pretty equations, nice cross referencing for figures, tables, and bibliography. PDF is one format it can convert to, RTF is another. As I’m not using a screen reader, I’m guessing, however, because latex is so old school, you should be able to do bold, italic, etc as needed with it.