Let's see...
Pay off mortgages, etc for all my family;
Buy a house as opposed to the apartment we own;
Set up trusts for my children so they have income for their lifetimes;
Pay for college for the kids;
Buy a car;
Get that uber-gaming computer I dream about, times 4 for all the gamers in the house;
Travel... oh, gods, I'd go see all the places I've wanted to see. Alone, so I could enjoy it.
That's the stuff for me.
I'd also have my lawyers set up a philanthropic trust to contribute to worthy causes after they were vetted for legitimacy. Diabetes research and autism research would be the first that came to mind, but the DAN folks can go screw.